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Selected clinical measurements (A) and metabolites (B) are compared between NW (n = 33), OB (n = 32), GDM-NW (n = 15) and GDM-OB (n = 16) women. The boxes represent the 25 th to 75 th percentiles with Tukey whiskers and the line indicating median. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 for group comparisons using Kruskal-Wallis analysis and Mann-Whitney-U statistics adjusted for multiple comparisons. Observed power for Kruskal-Wallis analysis was ≥ 0.8 for all variables except one (Valine, power = 0.4) C) Overview of significant differences. NW, women of normal weight; OB, women with obesity; GDM-NW, women with GDM and of normal weight; GDM-OB, women with GDM and obesity; <t>LepR,</t> soluble <t>leptin</t> receptor; HOMA-IR, homeostatic model assessment of insulin resistance; BCAA, branched chained amino acids.
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Selected clinical measurements (A) and metabolites (B) are compared between NW (n = 33), OB (n = 32), GDM-NW (n = 15) and GDM-OB (n = 16) women. The boxes represent the 25 th to 75 th percentiles with Tukey whiskers and the line indicating median. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 for group comparisons using Kruskal-Wallis analysis and Mann-Whitney-U statistics adjusted for multiple comparisons. Observed power for Kruskal-Wallis analysis was ≥ 0.8 for all variables except one (Valine, power = 0.4) C) Overview of significant differences. NW, women of normal weight; OB, women with obesity; GDM-NW, women with GDM and of normal weight; GDM-OB, women with GDM and obesity; <t>LepR,</t> soluble <t>leptin</t> receptor; HOMA-IR, homeostatic model assessment of insulin resistance; BCAA, branched chained amino acids.
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Selected clinical measurements (A) and metabolites (B) are compared between NW (n = 33), OB (n = 32), GDM-NW (n = 15) and GDM-OB (n = 16) women. The boxes represent the 25 th to 75 th percentiles with Tukey whiskers and the line indicating median. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 for group comparisons using Kruskal-Wallis analysis and Mann-Whitney-U statistics adjusted for multiple comparisons. Observed power for Kruskal-Wallis analysis was ≥ 0.8 for all variables except one (Valine, power = 0.4) C) Overview of significant differences. NW, women of normal weight; OB, women with obesity; GDM-NW, women with GDM and of normal weight; GDM-OB, women with GDM and obesity; <t>LepR,</t> soluble <t>leptin</t> receptor; HOMA-IR, homeostatic model assessment of insulin resistance; BCAA, branched chained amino acids.
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Selected clinical measurements (A) and metabolites (B) are compared between NW (n = 33), OB (n = 32), GDM-NW (n = 15) and GDM-OB (n = 16) women. The boxes represent the 25 th to 75 th percentiles with Tukey whiskers and the line indicating median. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 for group comparisons using Kruskal-Wallis analysis and Mann-Whitney-U statistics adjusted for multiple comparisons. Observed power for Kruskal-Wallis analysis was ≥ 0.8 for all variables except one (Valine, power = 0.4) C) Overview of significant differences. NW, women of normal weight; OB, women with obesity; GDM-NW, women with GDM and of normal weight; GDM-OB, women with GDM and obesity; LepR, soluble leptin receptor; HOMA-IR, homeostatic model assessment of insulin resistance; BCAA, branched chained amino acids.

Journal: PLOS One

Article Title: Metabolomics and glucose tolerance in pregnancy and postpartum: The PONCH study

doi: 10.1371/journal.pone.0335708

Figure Lengend Snippet: Selected clinical measurements (A) and metabolites (B) are compared between NW (n = 33), OB (n = 32), GDM-NW (n = 15) and GDM-OB (n = 16) women. The boxes represent the 25 th to 75 th percentiles with Tukey whiskers and the line indicating median. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 for group comparisons using Kruskal-Wallis analysis and Mann-Whitney-U statistics adjusted for multiple comparisons. Observed power for Kruskal-Wallis analysis was ≥ 0.8 for all variables except one (Valine, power = 0.4) C) Overview of significant differences. NW, women of normal weight; OB, women with obesity; GDM-NW, women with GDM and of normal weight; GDM-OB, women with GDM and obesity; LepR, soluble leptin receptor; HOMA-IR, homeostatic model assessment of insulin resistance; BCAA, branched chained amino acids.

Article Snippet: Leptin (Human Leptin Quantikine, R&D Systems, Minneapolis, MN; interassay coefficient of variation, 8.0% at 9 μg/l), the soluble leptin receptor (LepR) (Human Leptin R Quantikine, R&D Systems) and adiponectin (Human Adiponectin ELISA kit, Millipore, Billerica, MA; interassay coefficient of variation, 7.0% at 10.5 mg/l) were analysed simultaneously for all samples using ELISA.

Techniques: MANN-WHITNEY